Yunping Huang , Jia Xuan

Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 3   doi: 10.5376/jmr.2024.14.0014
Received: 28 Mar., 2024    Accepted: 10 May, 2024    Published: 31 May, 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Huang Y.P., and Xuan J., 2024, Molecular interactions between mosquito vectors and pathogens, Journal of Mosquito Research, 14(3): 135-146 (doi: 10.5376/jmr.2024.14.0014)

The interaction between mosquito vectors and pathogens is a key factor in the epidemiology of many infectious diseases, such as dengue, Zika virus, and malaria. Mosquitoes are not only carriers of pathogens, but also an environment in which pathogens can replicate and evolve. Therefore, disrupting the life cycle of pathogens in mosquito vectors can significantly reduce disease transmission. This study provides insights into the molecular mechanisms that control pathogen entry, survival, replication, and transmission in mosquito vectors. By employing a range of molecular tools, including genomic, transcriptomic, proteomic, and metabolomic approaches, as well as advanced technologies such as CRISPR-Cas9, we studied how pathogens recognize and bind to host cells, the pathways they use for entry, and their strategies to evade immunity and survive inside cells. This study reveals the potential of new molecular targets for vector control and disease prevention, which could lead to more effective public health interventions and reduce the global burden of mosquito-borne diseases.

Mosquito vectors; Pathogen interactions; Molecular mechanisms; Vector control; Disease transmission